Clinical phenotype of dementia after traumatic brain injury (TBI). 

 
   Lead Investigator:    Ramon Diaz-Arrastia
   Institution      :    University of Texas Southwestern Medical Center
   E-Mail           :    Ramon.Diaz-Arrastia@UTSouthwestern.edu
   Proposal ID      :    81


   Publications:


1  Sayed N, Culver C, Dams-O'Connor K, Hammond F, Diaz-Arrastia R
   Clinical phenotype of dementia after traumatic brain injury
   Journal Article  J Neurotrauma,30:1117-1122,2013,PMC3705947

   PUBLISHED



2  Sayed N, Culver C, Hammond R, Diaz-Arrastia R
   Clinical and Pathologic Phenotype of Dementia after Traumatic Brain Injury
   2012   Abstract  National Neurotrauma Society , 

   ACCEPTED



3  Sayed N, Diaz-Arrastia R
   Clinical and Pathologic Phenotype of Dementia after Traumatic Brain Injury (TBI)
   Abstract  Alzheimers Dement,7:S750,2011,

   PUBLISHED



4  Sayed N, Diaz-Arrastia R
   Clinical Phenotype of Dementia after Traumatic Brain Injury (TBI)
   Abstract  Neurology,74:A139,2010,

   PUBLISHED





   Proposal Description:
   We hypothesize that dementia associated with a single TBI earlier in life will differ from Alzheimer???s disease (AD ) and be phenotypically similar to the syndrome of chronic traumatic encephalopathy (CTE), which occurs after repeated concussions, such as incurred by boxers and football players1.    Specifically, the dementia in patients in the NACC UDS database with a history of ???TBI with chronic deficit??? will differ from AD and will be more similar to CTE in that:   (1)  Younger age of onset.   (2)  Slower rate of progression   (3)  Increased prevalence of mood and behavior symptoms early in the course   (4)  For those that have come to autopsy, the predominant pathology will be a tau-only dementia, with relatively modest plaque pathology.